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The Effects of Glucose-containing Dialysate during Dialysis in Maintenance
Haemodialysis Patients with Type 2 Diabetes: A Randomized Controlled Study

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L. He, H. Chen, L. Chen, J. Zhang, M. Liu, and L. Liu 1
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Hemodialysis Center, Department of Nephrology, West China Hospital, Sichuan, China
Background: Type 2 diabetes mellitus (T2DM) is the leading cause of end-stage renal disease (ESRD),
and approximately 26%~47% of haemodialysis patients have diabetes.At present, most haemodialysis
treatments use glucose-free dialysate. Howerver, the use of glucose-free dialysate resulted in an
increased incidence of asymptomatic hypoglycemia during dialysis treatment.

Objective: To compare the effects of glucose-containing dialysate and glucose-free dialysate in
Maintenance hemodialysis (MHD) patients with type 2 diabetes mellitus.

Methods: We selected 16 MHD patients with type 2 diabetes from March 2023 to April 2023. The
patients were randomly divided into a glucose-containing dialysate group (n=8) and a glucose-free
dialysate group (n=8) using SPSS 22.0. Glucose was monitored by Continuous Glucose Monitoring
Oral Presentation Abstracts
System (CGMS). The blood glucose related data of the two groups within 14 days were collected
according to the blood glucose extracted every 15 minutes by CGMS, and the incidence of
hypoglycemia, blood pressure and pulse rate during dialysis were compared between the two groups.

Results: The glucose target time in range (TIR) within 14 days was longer in the glucose-containing
dialysate group than in the non-glucose-containing dialysate group (P<0.05). TIR of glucose-
containing dialysate group was higher than that of glucose-free dialysate group on both dialysis days
and non-dialysis days (P<0.05). The frequency of hypoglycaemia in the glucose-containing dialysate
group was significantly lower than that in the glucose-free dialysate group at the second hour of
dialysis (P<0.05). There was no significant difference in blood pressure or pulse rate fluctuation
between the two groups.

Conclusion: In conclusion, the use of glucose-containing fluids, as compared with glucose-free fluids,
may be beneficial in targeting glucose levels in MHD patients with type 2 diabetes. Further sample size
increases are needed to demonstrate the effect of glucose-containing dialysate in MHD patients with
type 2 diabetes.

Keywords: hemodialysis, glucose-containing dialysite, type2 diabetes, hypoglycemia

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Correspondence: Lin Chen, Hemodialysis Center, Department of Nephrology, West China Hospital,
Sichuan, China
E-mail: clhxxuetou@163.com

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