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Study on the Dynamic Changes in Symptom Clusters in Lung Cancer Patients
Undergoing Chemotherapy

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X. Liu, Z. Wang, Q. Xia, S. Liao, and O. Chen 1
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Nursing School, Hunan University of Traditional Chinese Medicine, China, and Nursing department,
Hunan Provincial People’s Hospital, China

Background: The existing studies examining the relationship between symptom clusters and Traditional
Chinese Medicine (TCM) five-state personality in lung cancer patients undergoing chemotherapy are very
limited.

Objective: To investigate the distribution patterns of TCM five-state personality in lung cancer patients
undergoing chemotherapy at different time points, and to examine its correlation with symptom clusters.

Methods: From March to December 2021, we recruited 226 lung cancer patients undergoing chemotherapy at
the oncology ward of the First Affiliated Hospital of Hunan University of Chinese Medicine in Hunan, China using
a cluster sampling method. We collected participants’ general demographic information after recruitment, and
Oral Presentation Abstracts
assessed their TCM five-state personality (using Anderson Symptom Assessment Scale- Lung Cancer Module
Chinese Revised Version) and symptom clusters (using the five-state Personality Test Scale) before
chemotherapy and after the completion of each cycle (first, second, third, and fourth) of chemotherapy.

Results: During chemotherapy, lung cancer patients had five symptom clusters: emotion-related,
respiratory-related, digestive-related, disease feeling-related, and somatic-related. Digestive-related
symptom cluster correlated positively with the Shaoyin type during the second chemotherapy cycle
and with the Taiyin and Yinyang and peace types across all time points. Respiratory-related symptom
clusters correlated negatively with the lunar type during the first chemotherapy cycle, positively with
the Shaoyang type during the second, third, fourth chemotherapy cycles, and positively with the solar
type before chemotherapy and during the second, third, fourth chemotherapy cycles. Emotion-related
symptom clusters correlated positively with the shaoyin and taiyin types and negatively with the Yin-Yang
and peace types across all time points. Somatic-related symptom clusters positively correlated with the
lunar type during the third and fourth chemotherapy cycles.

Conclusion: Before lung cancer patients undergo chemotherapy, establishing a reference framework
can facilitate the incorporation of TCM’s “cure not ill” approach, thereby enhancing the effectiveness
of symptom management for lung cancer.

Keywords: lung cancer, chemotherapy, symptom cluster, TCM five-state personality, correlation
analysis

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Correspondence: Ouying CHEN, Nursing School, Hunan University of Traditional Chinese Medicine, China
E-mail: 1577554017@qq.com

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